NEW 3-PHENYL INDOLE DERIVATIVES ASSEMBLING AS ANTITUBERCULOSIS DRUG USING QSAR AND ADMET STUDY
The newly designed compounds of the 3-phenyl indole derivative show great antituberculosis activities. They become a solution for MDR-TB treatment. This study was conducted to design 3-phenyl indole compounds through the QSAR approach. QSAR study used multi-linear regression (MLR) analysis. ADMET-drug likeness of new compounds investigated through in silico. The result provided the best QSAR equation, which was pMIC = 40.52 + 4.531(QC6) – 9.989(QC8) – 12.567(QC9) + 2.803(HOMO) – 166.568(LUMO). The addition of donating groups in indole compounds could enhance antituberculosis activity. ADME-drug likeness analysis revealed that newly designed compounds were good properties and were non-toxic.